A new study conducted by the Irish national agriculture and food organisation, Cork University and The center of supplementary pharmabiotics was published in Microbiology. The study examined whether the Lactobacillus probiotic strain in combination with CLA can affect body fat levels in mice. 

A previous study (Racine, 2010 и Thom, 2001) connects the expenditure of the fatty acid  T10, C12 CLA with the decrease of body fat in adult people. On the other hand, another study shows that these kinds of fatty acids can prevent the growth of cancerous cells in the intestine.

In order to prove this researchers have transferred an enzyme-coded gene of skin bacteria P.acnes in  Lactobacillus paracasei. Afterwards, they have stimulated it to produce CLA t10, c12. Lastly, they added the end result to the food of mice. This lead to 4-fold increase of  CLA in the fatty acid composition of the tissues of the animals (in comparison to the second controlled probiotic strain). This shows that the intake of probiotics affects the metabolism of specific body parts. The research team states that  t10, c12 CLA are highly beneficial for the body. It also changes the composition of the body by decreasing fat levels and increasing other types of tissues in animals, as well as in people.

On of the well documented side effects of high doses of CLA is livers steatosis (abnormal retention of fatty lipids in the human cells). Because of this the team recommends a precisely designed dose of low levels of CLA in combination with high-quality probiotic supplement. This way the side effect can be avoided. 

Catherine Stanton, the research team lead shares that CLA can improve non-alcoholic liver obesity which often is a precursor to general obesity. Therefore, increased levels of liver CLA through a probiotic supplement can be of great therapeutic importance. What is more, fats are not an inert layer of our bodily composition. They are active and can cause inflammation. They present a risk factor for various diseases, including cancer. This research shows that there is a way to moderate that by introducing a probiotic strain in the intestine. Two groups of 8-week old mice were fed with CLA supplement added to their regular diet for a period of 8 weeks.Group one was given a combination of  t10, c12 CLA and  Lactobacillus paracasei. Group two was given a controlled strain of probiotic without CLA. A third group was given just CLA. The composition of fatty acids was established through chromatography with liquid gas after the mice were humanely killed and their organs were extrapolated.

Resource

Microbiology, (публикувано онлайн през декември 2010) DOI: 10.1099/mic.0.043406-0 Автори: Cody, R-C; Stanton, C.; O’Mahony, L.; Wall, R. ; Shanahan, F. ; Quigley, E.M; Fitzgerald, G.F; Paul Ross, R.